N-(4-氰基-2-氟苯基)乙酰胺合成路线 （共 12 条）
反应条件
1: 95 percent / SnCl2, HCl / diethyl ether; CH2Cl2 / 2 h
2: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux
3: CrO3, conc. H2SO4 / acetone; H2O
4: 85 percent / conc. HCl / H2O / 1 h / Heating
5: 64.4 percent / I2, HgO / acetic acid / 1 h / Ambient temperature
View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 95 percent / SnCl2, HCl / diethyl ether; CH2Cl2 / 2 h
2: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux
3: CrO3, conc. H2SO4 / acetone; H2O
4: 85 percent / conc. HCl / H2O / 1 h / Heating
5: Br2 / acetic acid
View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
