1-(2-环丙基乙基)-6-氟-1,2-二氢-4-羟基-2-氧代-3-喹啉羧酸乙酯合成路线 (共 1 条)
反应条件
1: diethyl malonate With sodium hydride in N,N-dimethyl acetamide
T=10 - 20°C; 0.5 h;
2: 1-(2-cyclopropylethyl)-6-fluorobenzo[d][1,3]oxazine-2,4-dione in N,N-dimethyl acetamide
T=120°C; 20 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/38571 A2, 2007 ;
Location in patent: Page/Page column 38-39 ;
WO 2007/038571 A2