6,7-二氢-7,9-二甲基-6-(5-甲基-2-呋喃基)-11-苯基嘧啶并[4',5':3,4]吡咯并[1,2-a]喹喔啉-8,10(5H,9)-二酮合成路线 （共 5 条）
反应条件
toluene-4-sulfonic acid in 1,2-dichloro-ethane
0.0833333 h; Reflux;
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
反应条件
1: sodium hydroxide / water / 72 h / 25 °C
2: zinc(II) chloride / chlorobenzene / 3 h / Reflux
3: water; bromine / tetrachloromethane; dichloromethane / 0.17 h / 50 °C
4: ethanol / 1 h / Reflux
5: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 0.08 h / Reflux
View Scheme
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
反应条件
1: zinc(II) chloride / chlorobenzene / 3 h / Reflux
2: water; bromine / tetrachloromethane; dichloromethane / 0.17 h / 50 °C
3: ethanol / 1 h / Reflux
4: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 0.08 h / Reflux
View Scheme
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
反应条件
1: water; bromine / tetrachloromethane; dichloromethane / 0.17 h / 50 °C
2: ethanol / 1 h / Reflux
3: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 0.08 h / Reflux
View Scheme
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
反应条件
1: ethanol / 1 h / Reflux
2: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 0.08 h / Reflux
View Scheme
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
