1: 70 percent / p-TsOH / benzene / 15 h / Heating 2: 92 percent / LiAlH4 / diethyl ether / 5 h / Ambient temperature 3: 81 percent / Ph3P*Br2, Et3N / CH2Cl2 / 7 h 4: 1.) lithium amide / 1.) HMPTA, 15 deg C, 1.5 h, 2.) HMPTA, a) 0-10 deg C, 1 h, b) 20-25 deg C, 12 h 5: 91 percent / aq. HCl / acetone / 1 h / Heating 6: 95 percent / H2, NaBH4, Ni(CH3COO)2*4H2O, NH2(CH2)2NH2 / ethanol View Scheme

lithium aluminium tetrahydride in diethyl ether

1: 70 percent / p-TsOH / benzene / 15 h / Heating 2: 92 percent / LiAlH4 / diethyl ether / 5 h / Ambient temperature 3: 81 percent / Ph3P*Br2, Et3N / CH2Cl2 / 7 h 4: 1.) lithium amide / 1.) HMPTA, 15 deg C, 1.5 h, 2.) HMPTA, a) 0-10 deg C, 1 h, b) 20-25 deg C, 12 h 5: 91 percent / aq. HCl / acetone / 1 h / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '19265308', constants.ctx, '0')">coppered zinc</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587194', constants.ctx, '0')">iodine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506104', constants.ctx, '0')">ethyl acetate</a> <br />T=110&deg;C;&nbsp;&nbsp;in Toluol unter Wasserstoff, anschliessend mit Bernsteinsaeure-aethylester-chlorid in Toluol;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 69 percent / diethyl ether / 4 h / 36 - 38 &deg;C<br />2: 60 percent / HCl / 2 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 69 percent / diethyl ether / 4 h / 36 - 38 &deg;C<br />2: 60 percent / HCl / 2 h / Heating<br /> <br /> &nbsp;