4,5-二氯-3-羟基哒嗪合成路线 （共 68 条）
参考文献
Pharmaceutical Bulletin, , vol. 5, p. 376,377
Pharmaceutical Bulletin, , vol. 6, p. 641
反应条件
sodium azide in tetrahydrofuran; water Substitution; 19 h; Heating;
参考文献
Chung, Hyun-A; Kweon, Deok-Heon; Kang, Young-Jin; Park, Jung-won; Yoon, Yong-Jin
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 4 p. 905 - 910
反应条件
zinc(II) chloride; lead(IV) acetate 20 h; Heating;
参考文献
Tetrahedron Letters, , vol. 45, # 48 p. 8781 - 8784
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
Ewing, William R.; Zhu, Yeheng; Ellsworth, Bruce A.
Patent: US2006/287323 A1, 2006 ;
Location in patent: Page/Page column 12 ;
US 20060287323 A1
反应条件
potassium carbonate in dimethyl sulfoxide T=50 - 60°C; 7 h;
参考文献
Cho, Su-Dong; Kweon, Deok-Heon; Kang, Young-Jin; Chung, Hyun-A.; Yoon, Yong-Jin
Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 3 p. 601 - 605
反应条件
sodium hydroxide; palladium on activated charcoal Hydrogenation;
参考文献
Eichenberger et al.
Helvetica Chimica Acta, 1956 , vol. 39, p. 1755,1762
反应条件
potassium hydroxide; tetrabutylammomium bromide in benzene T=54 - 58°C; 3 h;
参考文献
Kim, Sung-Kyu; Cho, Su-Dong; Kweon, Deok-Heon; Yoon, Yong-Jin; Kim, Jung-Ho; Heo, Jung-Nyoung
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 209 - 214
反应条件
zinc(II) chloride; lead(IV) acetate 11 h; Heating;
参考文献
Kim, Jeum-Jong; Park, Yong-Dae; Cho, Su-Dong; Kim, Ho-Kyun; Chung, Hyun A.; Lee, Sang-Gyeong; Falck; Yoon, Yong-Jin
Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8781 - 8784
反应条件
potassium carbonate in acetonitrile 12 h; Reflux;
参考文献
CEPHALON, INC.
Patent: WO2009/142732 A2, 2009 ;
Location in patent: Page/Page column 61-62 ;
WO 2009/142732 A2
反应条件
sodium nitrite in water; N,N-dimethyl-formamide 5 h; Heating;
参考文献
Frolov, Eugene B.; Lakner, Frederick J.; Khvat, Alexandre V.; Ivachtchenko, Alexandre V.
Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4693 - 4696
