3-氨基-6-((二苄基氨基)甲基)-1,2,4-噻嗪-5(2H)-酮合成路线 （共 2 条）
反应条件
1: 3-bromo-2-oxopropionic acid ethyl ester; N-Benzylbenzylamine in ethyl acetate
T=60 - 80°C; Industry scale;
2: aminoguanidine hydrogen carbonate in ethanol
24 h; RefluxIndustry scale;
参考文献
OSI PHARMACEUTICALS, INC.; DONG, Hanqing; MAO, Yunyu; MULVIHILL, Kristen, Michelle; RECHKA, Josef, A.; WERNER, Douglas, S.
Patent: WO2011/5909 A2, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
in ethanol
18 h; Heating; Yield given;
参考文献
Mitchell; Hill; Newton; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 697 - 699
