4-(2-甲氧基苯基)-2-氨基噻唑合成路线 （共 4 条）
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; CLEVELAND, Thomas; MAKINGS, Lewis R.; HAMILTON, Matthew; GROOTENHUIS, Peter D.J.
Patent: WO2005/26137 A2, 2005 ;
Location in patent: Page/Page column 246-247 ;
WO 2005/026137 A2
反应条件
copper(II) bis(trifluoromethanesulfonate) in 1,2-dichloro-ethane T=80°C; 2.5 h;
参考文献
Yadav; Reddy, B.V. Subba; Rao, Y. Gopala; Narsaiah
Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2381 - 2383
反应条件
iodine T=100°C; 8 h;
参考文献
Koppireddi, Satish; Komsani, Jayaram Reddy; Avula, Sreenivas; Pombala, Sujitha; Vasamsetti, Satishbabu; Kotamraju, Srigiridhar; Yadla, Rambabu
European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 305 - 313
反应条件
aluminum oxide; ammonium acetate; silica gel in benzene T=90°C; 16 h;
参考文献
Jung, Kwan-Young; Kim, Soo-Kyung; Gao, Zhan-Guo; Gross, Ariel S.; Melman, Neli; Jacobson, Kenneth A.; Kim, Yong-Chul
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 3 p. 613 - 623
