1H-吲哚-7-羧酸甲酯合成路线 （共 18 条）
反应条件
TiCl3 1.) DMF, reflux, 13.5 h; 2.) water, MeOH, 7 min; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 10 p. 4116 - 4125
参考文献
Synthetic Communications, , vol. 27, # 12 p. 2033 - 2039
反应条件
hydrogenchloride in 1,4-dioxane; water
参考文献
Nihon Tokushu Noyaku Seizo K.K.
Patent: US4729998 A1, 1988 ;
反应条件
trichlorophosphate in N-methyl-acetamide
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate in 1,2-dichloro-ethane T=5°C; 2: 1H-Indole-7-carboxylic acid,methyl ester in 1,2-dichloro-ethane T=5 - 50°C; 2.5 h; 3: With water; sodium carbonate in dichloromethane T=20°C; 0.5 h;
参考文献
Abbott GmbH and Co. KG
Patent: US7049312 B1, 2006 ;
Location in patent: Page/Page column 112 ;
US 7049312 B1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating / reflux; 2: With water in tetrahydrofuran T=20°C;
参考文献
DECODE CHEMISTRY, INC.
Patent: WO2006/44415 A2, 2006 ;
Location in patent: Page/Page column 78; 106-107 ;
WO 2006/044415 A2
反应条件
1: 90.9 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 63.6 percent / MnO2 / CH2Cl2 / 110 h / Ambient temperature View Scheme
参考文献
Somei, Masanori; Saida, Yoshihiro; Komura, Naoko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4116 - 4125
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 °C 1.2: dimethylformamide / 2.5 h / 0 - 20 °C 2.1: NaOH / methanol; H2O / 8 h / Heating View Scheme
参考文献
Rigby, James H.; Burke, Patrick J.
Heterocycles, 2006 , vol. 67, # 2 p. 643 - 653
