2-羟基-5-(三氟甲氧基)苯甲醛合成路线 （共 6 条）
反应条件
boron tribromide in dichloromethane T=-20 - 0°C; 2 h; Inert atmosphere;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; HICKEN, Erik James; HUNT, Kevin W.; RODRIGUEZ, Martha E.; TANG, Tony P.; SIU, Michael
Patent: WO2013/148851 A1, 2013 ;
Location in patent: Paragraph 00244 ;
反应条件
1: 85 percent / HCl / CH2Cl2 2: 17 percent / n-BuLi; N,N,N',N'-tetramethylethylenediamine View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 12 p. 3162 - 3165
反应条件
1: 2-(4-trifluoromethoxy-phenoxy)-tetrahydro-pyran With n-butyllithium; N,N,N',N,-tetramethylethylenediamine 2: N,N-dimethyl-formamide
参考文献
Peschke, Bernd; Bak, Sonja; Hohlweg, Rolf; Nielsen, Rita; Viuff, Dorthe; Rimvall, Karin
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3162 - 3165
反应条件
1: 4-(Trifluoromethoxy)phenol With magnesium methanolate in methanol 2: formaldehyd in toluene 3: With hydrogenchloride in water
参考文献
European Journal of Medicinal Chemistry, , vol. 73, p. 177 - 186
反应条件
1: 2-hydroxy-5-trifluoromethoxy-benzaldehyde With potassium carbonate in DMF (N,N-dimethyl-formamide) 0.5 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide)
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1460062 A1, 2004 ;
Location in patent: Page 70 ;
反应条件
sodium hydroxide; silver nitrate in water T=0°C; 0.166667 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 21 p. 5661 - 5675
