N-(叔-丁氧基羰基)-3-碘-L-丙氨酸甲酯合成路线 （共 45 条）
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane T=20°C; Inert atmosphere;
参考文献
Crich, David; Rahaman, Md. Yeajur
Journal of Organic Chemistry, 2009 , vol. 74, # 17 p. 6792 - 6796
反应条件
sodium iodide in acetone 12 h; Heating;
参考文献
Stocking, Emily M.; Schwarz, Jessie N.; Senn, Hans; Salzmann, Michael; Silks, Louis A.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 16 p. 2443 - 2447
反应条件
1: 99 percent / Et3N / acetonitrile / 6 h 2: 84 percent / triphenylphosphine; imidazole; I2 / CH2Cl2 / 2.5 h / 0 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 24 p. 4599 - 4602
反应条件
sodium iodide in acetone Yield given;
参考文献
Synlett, , vol. 1997, # 2 p. 169 - 170
反应条件
1: KHCO3 / dimethylformamide 2: 76 percent / triphenylphosphine; imidazole; I2 / CH2Cl2 / 3.5 h / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 16 p. 2857 - 2859
反应条件
1H-imidazole; iodine; triphenylphosphine
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 15 p. 4427 - 4431
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With iodine; zinc in N,N-dimethyl-formamide T=20°C; Inert atmosphere; 2: 4-hydroxyiodobenzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide T=20°C; Negishi coupling; Inert atmosphere;
参考文献
Ross, Andrew J.; Lang, Hannah L.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 1 p. 245 - 248
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With iodine; zinc in N,N-dimethyl-formamide T=20°C; Inert atmosphere; 2: 4-bromo-phenol With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide T=50°C; Negishi coupling; 3 h; Inert atmosphere;
参考文献
Ross, Andrew J.; Lang, Hannah L.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 1 p. 245 - 248
反应条件
1: With bis (triortho-tolylphosphine)palladium(II) chloride; zinc in tetrahydrofuran; N,N-dimethyl acetamide T=60°C; Condensation; 3 h; 2: With hydrogen; palladium on activated charcoal in tetrahydrofuran T=20°C; Hydrogenolysis; 21 h;
参考文献
Kendall, John T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 505 - 514
反应条件
N,N,N',N,-tetramethylethylenediamine; PdCl2(Amphos)2; zinc in water T=65°C; Negishi coupling reaction; 4 h; Inert atmosphere;
参考文献
Ross, Andrew J.; Dreiocker, Frank; Schae Fer, Mathias; Oomens, Jos; Meijer, Anthony J.H.M.; Pickup, Barry T.; Jackson, Richard F.W.
Journal of Organic Chemistry, 2011 , vol. 76, # 6 p. 1727 - 1734
