N-(叔-丁氧基羰基)-3-碘-L-丙氨酸甲酯合成路线 （共 45 条）
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With chloro-trimethyl-silane; ethylene dibromide; zinc in tetrahydrofuran T=45°C; 1.45 h; 2: Sphenyl N-benzyloxycarbonylaminoethanothioate With tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran T=45°C; 4.5 h;
参考文献
Estiarte, M.Angels; Diez, Anna; Rubiralta, Mario; Jackson, Richard F.W
Tetrahedron, 2001 , vol. 57, # 1 p. 157 - 161
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With chloro-trimethyl-silane; ethylene dibromide; zinc in tetrahydrofuran T=45°C; 1.45 h; 2: thioacetic acid S-ethyl ester With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=45°C; 4.5 h;
参考文献
Estiarte, M.Angels; Diez, Anna; Rubiralta, Mario; Jackson, Richard F.W
Tetrahedron, 2001 , vol. 57, # 1 p. 157 - 161
反应条件
1: With bis (triortho-tolylphosphine)palladium(II) chloride; zinc in tetrahydrofuran; N,N-dimethyl acetamide T=60°C; Condensation; 3 h; 2: With hydrogen; palladium on activated charcoal in tetrahydrofuran T=20°C; Hydrogenolysis; 21 h;
参考文献
Kendall, John T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 505 - 514
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride; zinc in tetrahydrofuran; N,N-dimethyl acetamide T=60°C; Condensation; reduction; 3 h; Title compound not separated from byproducts;
参考文献
Kendall, John T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 505 - 514
反应条件
in diethyl ether T=-10°C; 5 h;
参考文献
Tetrahedron Letters, , vol. 25, # 26 p. 2759 - 2762
反应条件
in diethyl ether T=-60°C; 5 h;
参考文献
Tetrahedron Letters, , vol. 25, # 26 p. 2759 - 2762
反应条件
in diethyl ether T=-60°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 25, # 26 p. 2759 - 2762
反应条件
in diethyl ether T=-60°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 25, # 26 p. 2759 - 2762
反应条件
in diethyl ether T=-60°C; 3 h; Yield given. Title compound not separated from byproducts;
参考文献
Bajgrowicz, J. A.; Hallaoui, A. El; Jacquier, R.; Pigiere, Ch.; Viallefont, Ph.
Tetrahedron, 1985 , vol. 41, # 10 p. 1833 - 1845
反应条件
in diethyl ether T=-60°C; 3 h; Yield given. Title compound not separated from byproducts;
参考文献
Bajgrowicz, J. A.; Hallaoui, A. El; Jacquier, R.; Pigiere, Ch.; Viallefont, Ph.
Tetrahedron Letters, 1984 , vol. 25, # 26 p. 2759 - 2762
