3-氰基-4-甲基-2-吡啶酮合成路线 （共 10 条）
反应条件
sulfuric acid T=50°C; 2 h;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2008/56898 A1, 2008 ;
Location in patent: Page/Page column 15 ;
WO 2008/056898 A1
反应条件
1: With piperidinium acetate in toluene T=20°C; 16.3 h; 2: With sulfuric acid T=50°C; 2 h;
参考文献
US2010/16376 A1, ;
Page/Page column 7 ;
US 20100016376 A1
反应条件
sulfuric acid T=20 - 50°C; 5.33333 h;
参考文献
EP1679003 A1, ;
Page/Page column 21 ;
反应条件
ammonia T=150°C; 5 h; in a bomb;
参考文献
Smetskaya, N. I.; Mukhina, N. A.; Granik, V. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 6 p. 650 - 653
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 6 p. 799 - 802
反应条件
1: 60 percent / 1 h / 50 °C 2: 46 percent / 10percent alcohol solution of ammonia / 5 h / 150 °C / in a bomb View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 20, # 6 p. 650 - 653
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 20, # 6 p. 799 - 802
反应条件
1)toluene, reflux 30 min 2)dimethylformamide, reflux 3h; Yield given. Multistep reaction;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 20, # 6 p. 650 - 653
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 20, # 6 p. 799 - 802
反应条件
in 1,4-dioxane Substitution; Condensation; Methylation; 4 h; Heating;
参考文献
Al-Mousawi; George; Elnagdi
Pharmazie, 1999 , vol. 54, # 8 p. 571 - 574
反应条件
phosphorus pentachloride in water
参考文献
Gupton, Bernard Franklin
Patent: US2002/52507 A1, 2002 ;
反应条件
1.1: trichlorophosphate / 2 h / 35 °C / Reflux 2.1: sulfuric acid / 4 h / 50 - 105 °C 2.2: 1.5 h / 60 - 65 °C 2.3: pH 7 / Cooling with ice 3.1: sodium hypochlorite; sodium hydroxide / methanol; water / 4 h / 10 - 60 °C View Scheme
参考文献
Ge, Xin; Chen, Han-Geng; Cao, Chang-Hui; Liu, Jin-Qiang; Qian, Chao; Chen, Xin-Zhi
Research on Chemical Intermediates, 2011 , vol. 37, # 6 p. 599 - 604
反应条件
1: With trichlorophosphate T=35°C; 2.25 h; Reflux; 2: With sulfuric acid T=50 - 110°C;
参考文献
Zhao, Qian; Chen, Han-Geng; Qian, Chao; Chen, Xin-Zhi
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 145 - 148
