1: 4'-amino-3'-bromoacetophenone With sulfuric acid in acetic acid T=0°C; 0.166667 h; 2: With sodium nitrite in water; acetic acid 0.5 h; 3: copper (I) cyanide; potassium cyanide in water; acetic acid T=0 - 20°C; 2.5 h;

hydrogenchloride; sodium nitrite 1.) H2O, 5 deg C; 2.) 40-50 deg C, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;

1: 93.4 percent / conc. H2SO4 / H2O; acetic acid / 5 h / Heating 2: 65.5 percent / K2CO3, Cu / 2 h / 157 - 170 °C 3: 95.1 percent / conc. H2SO4 / 4.5 h / Heating 4: 1.) sulfur, morpholine; 2.) KOH / 1.) reflux, 17 h; 2:) H2O, 95percent EtOH, reflux, 16 h View Scheme