4,5-二氯-2-甲基哒嗪-3-酮合成路线 （共 29 条）
反应条件
sodium methylate in methanol
参考文献
Wriede; Ulrich; Wuerzer; Bruno; Meyer; Norbert; Westphalen; Karl-Otto
Patent: US5123952 A1, 1992 ;
反应条件
sodium carbonate; PdCl2(PEt3)2 in water; N,N-dimethyl-formamide
Suzuki coupling;
参考文献
Barbay, Kent; Dyatkin, Alexey B.; Gong, Yong; He, Wei; Miskowski, Tamara A.
Patent: US2005/192279 A1, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
sodium carbonate; PdCl2(PEt3)2 in N,N-dimethyl-formamide
T=20°C; Suzuki coupling; 5 h;
参考文献
Gong, Yong; He, Wei
Heterocycles, 2004 , vol. 62, p. 851 - 856
反应条件
in methanol; ethanol
3 h; Heating;
参考文献
Matsuo; Tsukamoto; Takagi; Sato
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 832 - 842
反应条件
1: With water; potassium hydroxide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=125°C; 4 h;
2: With hydrogenchloride in water
参考文献
PIERRE FABRE MEDICAMENT; DUPONT-PASSELAIGUE, Elisabeth; MIALHE, Samuel; RIEU, Jean-Pierre; JUNQUERO, Didier; VALEILLE, Karine
Patent: WO2011/15629 A1, 2011 ;
Location in patent: Page/Page column 58 ;
WO 2011/015629 A1
反应条件
1: 81 percent / hydriodic acid / 24 h / Heating
2: 90 percent / bis(triphenylphosphine)palladium(II) dichloride / toluene / Heating
View Scheme
参考文献
Coelho, Alberto; Sotelo, Eddy; Novoa, Hector; Peeters, Oswald M.; Blaton, Norbert; Ravina, Enrique
Tetrahedron, 2004 , vol. 60, # 52 p. 12177 - 12189
反应条件
1: 81 percent / hydriodic acid / 24 h / Heating
2: bis(triphenylphosphine)palladium(II) dichloride / toluene / Heating
3: hydrochloric acid / 12 h / Heating
View Scheme
参考文献
Coelho, Alberto; Sotelo, Eddy; Novoa, Hector; Peeters, Oswald M.; Blaton, Norbert; Ravina, Enrique
Tetrahedron, 2004 , vol. 60, # 52 p. 12177 - 12189
反应条件
in methanol
10 h; Ambient temperature;
参考文献
Kaji; Nagashima; Ohta; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1249 - 1255
反应条件
1: With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
Suzuki cross-coupling; 24 h; Heating;
2: With sulfuric acid
17 h; Heating;
3: With trichlorophosphate
3 h; Heating;
参考文献
Riedl, Zsuzsanna; Monsieurs, Katrien; Krajsovszky, Gabor; Dunkel, Petra; Maes, Bert U.W.; Tapolcsanyi, Pal; Egyed, Orsolya; Boros, Sandor; Matyus, Peter; Pieters, Luc; Lemiere, Guy L.F.; Hajos, Gyoergy
Tetrahedron, 2006 , vol. 62, # 1 p. 121 - 129
