6-氯-8-溴咪唑并[1,2-b]哒嗪合成路线 (共 3 条)
反应条件
toluene-4-sulfonic acid in isopropyl alcohol T=80°C; 20 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu
Patent: WO2013/64445 A1, 2013 ;
Location in patent: Page/Page column 51 ;
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO); SNODIN, Michael D; PASTOR FERNANDEZ, Joaquín; MARTÍNEZ GONZÁLEZ, Sonia; BLANCO-APARICIO, Carmen; LORENZO GARCÍA, Milagros; RAMOS LIMA, Francisco Javier
Patent: WO2013/5041 A1, 2013 ;
Location in patent: Page/Page column 71 ;
WO 2013/005041 A1
反应条件
1: in ethanol; water 2 h; Reflux; 2: With sodium carbonate in ethanol; water; ethyl acetate
参考文献
WO2011/51342 A1, ;
Page/Page column 69 ;
WO 2011/051342 A1