(S)-3-(boc-氨基)-1-氯-2-丁酮合成路线 （共 5 条）
反应条件
1: NaBH4 / toluene; ethanol / -78 - 20 °C 2: 100 percent / KOH / ethanol / 20 °C View Scheme
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-75°C; 0.166667 h;
参考文献
Chen, Ping; Cheng, Peter T. W.; Spergel, Steven H.; Zahler, Robert; Wang, Xuebao; Thottathil, John; Barrish, Joel C.; Polniaszek, Richard P.
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3175 - 3178
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-90°C; Kowalski homologation;
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4539312 A1, 1985 ;
反应条件
sodium tetrahydroborate in ethanol; toluene
T=-78 - 20°C;
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
