3-甲基-3-氧杂环丁烷乙酸合成路线 （共 2 条）
反应条件
water; sodium hydroxide in methanol
T=40°C; 12 h;
参考文献
GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;
Location in patent: Page/Page column 171 ;
反应条件
1.1: copper(l) iodide; chloro-trimethyl-silane / tetrahydrofuran / 0.25 h / 20 °C / |Inert atmosphere
1.2: 1.17 h / -15 - 25 °C
2.1: water; sodium hydroxide / methanol / 12 h / 40 °C
View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;
