1,6-二氢-6-氧代-3-吡嗪羧醛合成路线 (共 1 条)
反应条件
1: triethylsilane; trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere 3: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 2 h / 20 °C View Scheme
参考文献
Kaila, Neelu; Huang, Adrian; Moretto, Alessandro; Follows, Bruce; Janz, Kristin; Lowe, Michael; Thomason, Jennifer; Mansour, Tarek S.; Hubeau, Cedric; Page, Karen; Morgan, Paul; Fish, Susan; Xu, Xin; Williams, Cara; Saiah, Eddine
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5088 - 5109