4-溴-2-(三氟甲氧基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane in methanol T=65°C; P=1875.19 Torr; 4 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/40440 A1, 2007 ;
Location in patent: Page/Page column 135 ;
WO 2007/040440 A1
反应条件
triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane T=65°C; P=2625.26 Torr; 3.66667 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/40440 A1, 2007 ;
Location in patent: Page/Page column 113-114 ;
WO 2007/040440 A1
反应条件
hydrogenchloride Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28952 A1, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=120°C; 0.166667 h; Microwave irradiation; 2: With hydrogenchloride; water in tetrahydrofuran; dichloromethane pH=1;
参考文献
WO2007/40440 A1, ;
Page/Page column 135 ;
WO 2007/040440 A1
