(-)-4,5-双[羟基(二苯基)甲基]-2,2-二甲基-1,3-二氧戊环合成路线 （共 9 条）
反应条件
1: bromobenzene With n-butyllithium in diethyl ether; hexane T=20°C; 2 h; 2: dimethyl (4R,5R)-(+)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate in diethyl ether; hexane T=20°C;
参考文献
Mueller, Simona; Afraz, Marcel Cyrus; De Gelder, Rene; Ariaans, Gerry J. A.; Kaptein, Bernard; Broxterman, Quirinus B.; Bruggink, Alle
European Journal of Organic Chemistry, 2005 , # 6 p. 1082 - 1096
反应条件
1: bromobenzene With magnesium in tetrahydrofuran 2: trans-(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylic acid diethyl ester in tetrahydrofuran 6 h; Heating;
参考文献
Du, Haifeng; Zhao, Dongbo; Ding, Kuiling
Chemistry - A European Journal, 2004 , vol. 10, # 23 p. 5964 - 5970
反应条件
1: 93 percent 2: 46 percent / diethyl ether / 2 h reflux, 15 h room t. View Scheme
参考文献
Helvetica Chimica Acta, , vol. 70, p. 954 - 974
参考文献
Goldberg, Israel; Stein, Zafra; Weber, Edwin; Doerpinghaus, Norbert; Franken, Sibylle
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1990 , # 6 p. 953 - 963
反应条件
in diethyl ether T=-78°C; 4 h; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 119, # 39 p. 9130 - 9136
参考文献
Tetrahedron, , vol. 53, # 45 p. 15469 - 15485
反应条件
in diethyl ether 3 h;
参考文献
Thompson, Lawrence C.; Knight, Kyle S.; Pennington, William T.
Journal of Chemical Crystallography, 2003 , vol. 33, # 5-6 p. 403 - 407
反应条件
1: acetophenone With sodium tetrahydroborate in water T=20°C; 2 h; 2: (-)-(R,R)-TADDOL in water 3 h;
参考文献
Miyamoto; Yasaka; Takaoka; Tanaka; Toda
Enantiomer, 2001 , vol. 6, # 1 p. 51 - 55
反应条件
1: 1-phenyl-propan-1-one With sodium tetrahydroborate in water T=20°C; 2 h; 2: (-)-(R,R)-TADDOL in water 3 h;
参考文献
Enantiomer, , vol. 6, # 1 p. 51 - 55
