4-溴-1H-吡咯-2-羧酸甲酯合成路线 （共 15 条）
反应条件
Ascophyllum nodosum vanadate(V)-dependent bromoperoxidase I; dihydrogen peroxide; sodium bromide in tert-butyl alcohol T=23°C; pH=6.2; 24 h; aq. bufferEnzymatic reaction;
参考文献
Green Chemistry, , vol. 13, # 1 p. 102 - 108
反应条件
2-(n-morpholino)ethanesulfonic acid; VBrPO(AnI) bromoperoxidase; dihydrogen peroxide; sodium bromide in water; tert-butyl alcohol T=20°C; pH=6.2; ConcentrationReagent/catalyst;
参考文献
Wischang, Diana; Radlow, Madlen; Hartung, Jens
Dalton Transactions, 2013 , vol. 42, # 33 p. 11926 - 11940
反应条件
sodium methylate 0.333333 h; Ambient temperature;
参考文献
Kitamura, Chitoshi; Yamashita, Yoshiro
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 10 p. 1443 - 1447
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DEVASTHALE, Pratik; WASHBURN, William N.; RENDUCHINTALA, Kishore V.; SRIDHAR, Radhakrishnan
Patent: WO2010/42682 A1, 2010 ;
Location in patent: Page/Page column 50 ;
WO 2010/042682 A1
反应条件
in methanol T=0°C; 0.833333 h;
参考文献
WO2004/72063 A1, ;
Page 29 ;
WO 2004/072063 A1
反应条件
1: 69 percent / Br2 / CHCl3 / 0.17 h / Ambient temperature 2: 82 percent / NaOMe / 0.33 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 10 p. 1443 - 1447
反应条件
sodium tetrahydroborate in tetrahydrofuran T=-78°C; 0.666667 h;
参考文献
Organic Letters, , vol. 8, # 14 p. 2961 - 2964
反应条件
ammonium metavanadate; perchloric acid; dihydrogen peroxide; sodium bromide in water; tert-butyl alcohol T=25°C; pH=1; regioselective reaction;
参考文献
Tetrahedron, , vol. 67, # 22 p. 4048 - 4054
反应条件
bromine in water; tert-butyl alcohol T=25°C; regioselective reaction;
参考文献
Tetrahedron, , vol. 67, # 22 p. 4048 - 4054
反应条件
1: sodium methylate / 0.5 h / 23 °C / Inert atmosphere 2: Ascophyllum nodosum vanadate(V)-dependent bromoperoxidase I; dihydrogen peroxide; sodium bromide / tert-butyl alcohol / 24 h / 23 °C / pH 6.2 / aq. buffer; Enzymatic reaction View Scheme
参考文献
Green Chemistry, , vol. 13, # 1 p. 102 - 108
