4-溴-1H-吡咯-2-羧酸甲酯合成路线 （共 15 条）
反应条件
1: methanol / 0.67 h / 23 °C / Inert atmosphere 2: bromine / water; tert-butyl alcohol / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 67, # 22 p. 4048 - 4054
反应条件
1: methanol / 0.67 h / 23 °C / Inert atmosphere 2: Ascophyllum nodosum vanadate(V)-dependent bromoperoxidase I; dihydrogen peroxide; sodium bromide / water; tert-butyl alcohol / 24 h / 23 °C / pH 6.2 / aq. buffer; Enzymatic reaction View Scheme
参考文献
Tetrahedron, , vol. 67, # 22 p. 4048 - 4054
反应条件
potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(di-tert-butylphosphino)ferrocene in 1,4-dioxane; water T=95°C; 3 h; Inert atmosphere;
参考文献
Eli Lilly and Company
Patent: US2012/202797 A1, 2012 ;
Location in patent: Page/Page column 5-6 ;
US 20120202797 A1
反应条件
boron trifluoride diethyl etherate in dichloromethane T=0°C;
参考文献
Muratake, Hideaki; Abe, Itsuko; Natsume, Mitsutaka
Tetrahedron Letters, 1994 , vol. 35, # 16 p. 2573 - 2576
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile 4 h; Ambient temperature;
参考文献
Artis; Cho; Jaime-Figueroa; Muchowski
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2456 - 2466
