暂无反应条件数据

copper(l) iodide in tetrahydrofuran T=-40°C; 8 h; regioselective reaction;

1: 1,5-dibromo-pentane With magnesium in diethyl ether Heating; 2: methyl 3-N,N-dimethylamino-(2R)-(4-methoxyphenyl)propionate in diethyl ether T=20°C; Further stages.;

1: ammonium acetate; acetic acid / 3 h / |Sonication 2: p-toluenesulfonic acid monohydrate; N1,N1-dimethyl-N2-(((S)-pyrrolidin-2-yl)methyl)ethane-1,2-diamine / N,N-dimethyl-formamide / 24 h / 20 °C 3: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / 0 °C 4: sodium tetrahydroborate; NiII chloride hexahydrate / methanol / 1.5 h / 0 °C / |Inert atmosphere 5: triethylamine / 20 °C 6: triethylamine / dichloromethane / 14 h / 0 °C / |Reflux 7: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 20 °C / |Reflux 8: sodium hydride / tetrahydrofuran / 0 - 20 °C 9: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C 10: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / |Reflux View Scheme

1: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / 0 °C 2: sodium tetrahydroborate; NiII chloride hexahydrate / methanol / 1.5 h / 0 °C / |Inert atmosphere 3: triethylamine / 20 °C 4: triethylamine / dichloromethane / 14 h / 0 °C / |Reflux 5: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 20 °C / |Reflux 6: sodium hydride / tetrahydrofuran / 0 - 20 °C 7: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C 8: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / |Reflux View Scheme

1: triethylamine / dichloromethane / 14 h / 0 °C / |Reflux 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 20 °C / |Reflux 3: sodium hydride / tetrahydrofuran / 0 - 20 °C 4: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C 5: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / |Reflux View Scheme

1: sodium hydride / tetrahydrofuran / 0 - 20 °C 2: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / |Reflux View Scheme

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.5 h 2: diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide; titanium(IV) isopropylate / dichloromethane / 6 h / -50 °C / |Molecular sieve 3: triethylamine / dichloromethane / 0.25 h / 0 °C 4: water / 10 h / 20 °C 5: copper(l) iodide / tetrahydrofuran / 8 h / -40 °C View Scheme

1: diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide; titanium(IV) isopropylate / dichloromethane / 6 h / -50 °C / |Molecular sieve 2: triethylamine / dichloromethane / 0.25 h / 0 °C 3: water / 10 h / 20 °C 4: copper(l) iodide / tetrahydrofuran / 8 h / -40 °C View Scheme

1: triethylamine / dichloromethane / 0.25 h / 0 °C 2: water / 10 h / 20 °C 3: copper(l) iodide / tetrahydrofuran / 8 h / -40 °C View Scheme