O-去甲文拉法辛合成路线

93413-61-71-[1-(4-苄氧基苯基)-2-(二甲基氨基)乙基]环己醇

参考文献

ZENTIVA, K.S.; HRUBY, Petr; RIDVAN, Ludek; RADL, Stanislav; PLACEK, Lukas
Patent: WO2011/6455 A2, 2011 ;
Location in patent: Page/Page column 8 ;

93413-69-5文拉法辛

93413-62-8O-去甲文拉法辛

参考文献

TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/120923 A1, 2007 ;
Location in patent: Page/Page column 18; 20-21 ;

1268269-56-2

93413-62-8O-去甲文拉法辛

参考文献

ZENTIVA, K.S.; HRUBY, Petr; RIDVAN, Ludek; RADL, Stanislav; PLACEK, Lukas
Patent: WO2011/6455 A2, 2011 ;
Location in patent: Page/Page column 9 ;

1000377-24-1

93413-62-8O-去甲文拉法辛

参考文献

ZENTIVA, K.S.; HRUBY, Petr; RIDVAN, Ludek; RADL, Stanislav; PLACEK, Lukas
Patent: WO2011/6455 A2, 2011 ;
Location in patent: Page/Page column 9; 10 ;

99300-78-4盐酸文拉法辛

93413-62-8O-去甲文拉法辛

参考文献

CADILA HEALTHCARE LIMITED
Patent: US2012/264828 A1, 2012 ;
Location in patent: Page/Page column 7-8 ;

918344-20-44-羟基-α-(1-羟基环己基)苯乙腈+

124-40-3二甲胺

93413-62-8O-去甲文拉法辛

参考文献

EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe
Patent: WO2009/144517 A1, 2009 ;
Location in patent: Page/Page column 20-21; 23 ;

64-18-6甲酸+

93413-56-05-(4-甲氧基苯基)-3-甲基-1-氧杂-3-氮杂螺[5.5]十一烷盐酸盐

93413-62-8O-去甲文拉法辛

参考文献

PHARMATHEN S.A.; KOFTIS, Theoharis V.; GEORGOPOULOU, Ioanna; STRONGILOS, Alexandros; LIEPOURI, Fotini; PANAGIOTIDIS, Theodoros; LITHADIOTI, Alexandra
Patent: WO2011/72703 A1, 2011 ;
Location in patent: Page/Page column 7-8 ;

149289-29-21-[2-氨基-1-(4-羟基苯基)乙基]环己醇+

50-00-0甲醛

93413-62-8O-去甲文拉法辛

参考文献

MEDICHEM, S.A.
Patent: US2010/121108 A1, 2010 ;
Location in patent: Page/Page column 4-5 ;

300827-87-64-(2-(二甲基氨基)-1-(1-羟基环己基)乙基)苯酚盐酸盐

93413-62-8O-去甲文拉法辛

参考文献

CHEMO IBERICA, S.A.; MOLINA PONCE, Andres; GRACIA GARCIA, Jesus Angel
Patent: WO2010/79046 A1, 2010 ;
Location in patent: Page/Page column 9-10 ;

918344-20-44-羟基-α-(1-羟基环己基)苯乙腈+

506-59-2盐酸二甲胺

93413-62-8O-去甲文拉法辛

参考文献

CALYX CHEMICALS AND PHARMACEUTICALS LTD.
Patent: WO2009/84037 A2, 2009 ;
Location in patent: Page/Page column 5; 7; 9; 20-21 ;