文拉法辛合成路线

参考文献

Randox Laboratories, Limited; Benchikh, Elouard; McConnell, Ivan; Lowry, Philip; Fitzgerald, Peter
Patent: US2014/147859 A1, 2014 ;
Location in patent: Page/Page column ;

50-00-0甲醛+

93413-77-51-[2-氨基-1-(4-甲氧基苯基)乙基]环己醇

93413-70-85-(4-甲氧基苯基)-3-甲基-1-氧-3-氮杂并[5.5]十一烷+

93413-69-5文拉法辛

参考文献

US2009/5455 A1, ;

Page/Page column 6-7 ;

1094598-37-4文拉法辛N-氧化物

93413-69-5文拉法辛

参考文献

Gowda, Narendra B.; Rao, Gopal Krishna; Ramakrishna, Ramesha A.
Tetrahedron Letters, 2010 , vol. 51, # 43 p. 5690 - 5693

131801-70-2

93413-69-5文拉法辛

参考文献

US5043466 A1, ;

1047637-30-8

93413-69-5文拉法辛

参考文献

Panunzio, Mauro; Bandini, Elisa; D'Aurizio, Antonio; Xia, Zhining; Mu, Xiaojing
Synthesis, 2008 , # 11 p. 1753 - 1756

130198-05-91-(2-氨基-1-(4-甲氧基苯基)乙基)环己醇盐酸盐

93413-69-5文拉法辛

参考文献

WO2005/58796 A2, ;

Page/Page column 14 ;

323176-93-8乙基alpha-(p-甲氧基苯基)-beta-(二甲基氨基)丙酸酯+

111-24-0二溴戊烷

93413-69-5文拉法辛

参考文献

Chavan, Subhash P.; Khobragade, Dushant A.; Thakkar, Mahesh; Kalkote, Uttam R.
Synthetic Communications, 2007 , vol. 37, # 22 p. 3901 - 3906

50-00-0甲醛+

64-18-6甲酸+

130198-05-91-(2-氨基-1-(4-甲氧基苯基)乙基)环己醇盐酸盐

93413-69-5文拉法辛

参考文献

TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/47972 A2, 2007 ;
Location in patent: Page/Page column 21; 22 ;

104-47-2对甲氧基苯乙腈

93413-69-5文拉法辛

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3279 - 3281

93413-76-4(1-羟环己基)(4-甲氧基苯基)乙腈

93413-69-5文拉法辛

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3279 - 3281