1-[2-氨基-1-(4-甲氧基苯基)乙基]环己醇合成路线 （共 28 条）
反应条件
in water 20 - 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/47972 A2, 2007 ;
Location in patent: Page/Page column 17; 18 ;
反应条件
in 3,6,9,12,15,18,21,24,27-nonaoxanonacosane-1,29-diol T=190°C; 3 h; Product distribution / selectivity;
参考文献
Niddam-Hildesheim, Valerie; Shenkar, Natalia; Shachan-Tov, Sharona
Patent: US2008/139849 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
hydrogenchloride in ethyl acetate; isopropyl alcohol T=5 - 10°C; 0.666667 - 1 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/47972 A2, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With Na-selectride in tetrahydrofuran; toluene T=20 - 115°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water; toluene T=10°C; pH=1.0; Reflux; 3: With sodium hydroxide in water T=20°C; pH=10.3 - 10.5; Product distribution / selectivity;
参考文献
MEDICHEM, S.A.
Patent: US2010/121108 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
in 3,6,9,12,15,18,21,24,27-nonaoxanonacosane-1,29-diol T=190°C; 3 h; Product distribution / selectivity;
参考文献
Niddam-Hildesheim, Valerie; Shenkar, Natalia; Shachan-Tov, Sharona
Patent: US2008/139849 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
lithium aluminium tetrahydride; sodium hydrogencarbonate 1.) CH2Cl2, RT, 20 h, 2.) THF, reflux, 1.5 h; Multistep reaction;
参考文献
Yardley; Morris Husbands; Stack; Butch; Bicksler; Moyer; Muth; Andree; Fletcher III; James; Sielecki
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2899 - 2905
反应条件
1: With formic acid in water
2 h; Heating / reflux;
2: With sodium hydroxide in water
T=0°C; pH=~ 10;
参考文献
Solvay Pharmaceuticals, B.V.
Patent: US2009/5455 A1, 2009 ;
Location in patent: Page/Page column 6-7 ;
反应条件
formic acid in water
T=90 - 95°C; 1 h;
参考文献
Saravanan, Mohanarangam; Kumar, Karra Suresh; Reddy, Padi Pratap; Satyanarayana, Bollikonda
Synthetic Communications, 2010 , vol. 40, # 13 p. 1880 - 1886
