2-碘-3-硝基苯甲酸甲酯合成路线 （共 11 条）
反应条件
sulfuric acid 48 h; Heating;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2141150 A1, 2010 ;
Location in patent: Page/Page column 103-104 ;
反应条件
sulfuric acid; trimethyl orthoformate in methanol
反应条件
1.1: aq. NaOH; Hg(OAc)2; AcOH / H2O / 70 h / Heating 1.2: aq. HCl; aq. NaOH / Heating 1.3: 19.1 g / AcOH; KI; I2 / H2O / 24 h / Heating 2.1: 95 percent / H2SO4 / 48 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 62, # 20 p. 4829 - 4837
参考文献
Journal of the American Chemical Society, , vol. 80, p. 1947,1949
参考文献
Journal of the Chemical Society, , p. 493
反应条件
1: 2.) HNO3 / 1.) 1 h, room temperature, 2.) AcOH, 2.5 h, 10 +/- 5 deg C 2: 1.) aq. KOH, 2.) HCl, NaNO2, 3.) KI, I2 3: 93 percent / conc. H2SO4 / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2012 - 2022
反应条件
1: 1.) aq. KOH, 2.) HCl, NaNO2, 3.) KI, I2 2: 93 percent / conc. H2SO4 / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2012 - 2022
反应条件
air; tri-n-butylborane; water in benzene T=20°C;
参考文献
Medeiros, Matthew R.; Schacherer, Laura N.; Spiegel, David A.; Wood, John L.
Organic Letters, 2007 , vol. 9, # 22 p. 4427 - 4429
反应条件
copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=45°C; Sonogashira coupling; 48 h;
参考文献
Tetrahedron, , vol. 62, # 20 p. 4829 - 4837
反应条件
copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=45°C; Sonogashira coupling; 72 h;
参考文献
Tetrahedron, , vol. 62, # 20 p. 4829 - 4837
