2,4,6-三氯-5-嘧啶羧酸合成路线 （共 6 条）
反应条件
1: 2,4,6-trichloro-pyrimidine With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C;
2: carbon dioxide in tetrahydrofuran
T=20°C; 1 h;
3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2011/152273 A1, 2011 ;
Location in patent: Page/Page column 34 ;
反应条件
sulfur trioxide in diethyl ether; sulfuric acid
参考文献
Ciba-Geigy Corporation
Patent: US4507146 A1, 1985 ;
反应条件
sulfur trioxide in diethyl ether
参考文献
Ciba-Geigy Corporation
Patent: US4507146 A1, 1985 ;
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
参考文献
Yamada, Koichiro; Matsuki, Kenji; Omori, Kenji; Kikkawa, Kohei
Patent: US2004/142930 A1, 2004 ;
US 20040142930 A1
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
参考文献
ABBVIE INC.; Vasudevan, Anil; Penning, Thomas Dale; Chen, Huanming; Liang, Bo; Wang, Shaohui; Zhao, Zhongqiang; Chai, Dikun; Yang, Leifu; Gao, Yingxiang; Pliushchev, Marina
Patent: US2014/171429 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran
T=20°C; 2.25 h;
参考文献
ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang
Patent: WO2012/97478 A1, 2012 ;
Location in patent: Page/Page column 56-57 ;
