1: 80 percent / iodine / acetic acid / 3 h / Heating 2: 1.) ozone, 2.) water / 1.) dichloromethane, methanol, -25 deg C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11343078', constants.ctx, '0')">sodium tetrahydroborate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br />&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) lithium diisopropylamide / 1.) THF, 5 deg C, 15 min, 2.) room temp., 2 h<br />2: 91 percent / diethyl ether / 4 h / Ambient temperature<br />3: 92 percent / sodium borohydride / ethanol / Ambient temperature<br /> <br /> &nbsp;