(2E,4E,6R,7R)-7-羟基-4,6-二甲基-7-(4-硝基苯基)庚-2,4-二烯酸乙酯合成路线 （共 4 条）
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran
T=20°C; 0.333333 h;
2: (E)-(4R,5R)-5-hydroxy-2,4-dimethyl-5-(4-nitrophenyl)-pent-2-enal in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Zhang, Shilei; Duan, Wenhu; Wang, Wei
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 10-11 p. 1228 - 1234
反应条件
1.1: L-proline / dimethylformamide / 5 h / 0 °C
1.2: CH2Cl2; toluene / 3 h / Heating
2.1: NaH / tetrahydrofuran / 0.33 h / 20 °C
2.2: 96 percent / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Zhang, Shilei; Duan, Wenhu; Wang, Wei
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 10-11 p. 1228 - 1234
反应条件
1.1: 663 mg / γ-MnO2 / CH2Cl2 / 1 h / 20 °C
2.1: NaH / tetrahydrofuran / 0.33 h / 20 °C
2.2: 96 percent / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Zhang, Shilei; Duan, Wenhu; Wang, Wei
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 10-11 p. 1228 - 1234
反应条件
1.1: DIBAL-H / tetrahydrofuran; toluene / 1 h / -70 °C
2.1: 663 mg / γ-MnO2 / CH2Cl2 / 1 h / 20 °C
3.1: NaH / tetrahydrofuran / 0.33 h / 20 °C
3.2: 96 percent / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Zhang, Shilei; Duan, Wenhu; Wang, Wei
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 10-11 p. 1228 - 1234
