5-溴-2-氨基噻唑[5,4-b]并吡啶合成路线 (共 6 条)
反应条件
bromine; acetic acid T=-15 - 20°C; Inert atmosphere;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/318425 A1, 2009 ;
Location in patent: Page/Page column 39-40 ;
US 20090318425 A1
反应条件
1: With hydrogenchloride; water 1 h; Reflux; 2: in water T=20°C; pH=10;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2009/129211 A1, 2009 ;
Location in patent: Page/Page column 35; 37 ;
WO 2009/129211 A1
反应条件
1: red phosphorus; toluene; bromine / 130 °C 2: SnCl2; aqueous HCl 3: bromine; acetic acid View Scheme
参考文献
Yakugaku Zasshi, , vol. 71, p. 662,665
Chem.Abstr., , p. 8109
反应条件
1: SnCl2; aqueous HCl 2: bromine; acetic acid View Scheme
参考文献
Yakugaku Zasshi, , vol. 71, p. 662,665
Chem.Abstr., , p. 8109
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2009/129211 A1, 2009 ;
Location in patent: Page/Page column 35; 37 ;
WO 2009/129211 A1
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; GONG, Xianchang; HIROSE, Masaaki; JIN, Bohan; ZHOU, Feng
Patent: WO2010/8847 A2, 2010 ;
Location in patent: Page/Page column 123 ;