8-苄基-3,8-二氮杂双环[3.2.1]辛烷合成路线 （共 12 条）
反应条件
N,N'-dimethyl-barbituric acid; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triphenylphosphine in dichloromethane 3 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/81995 A2, 2007 ;
Location in patent: Page/Page column 191 ;
WO 2007/081995 A2
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 70°C; 3 h; Inert atmosphere;
参考文献
LUPIN LIMITED; JANA, Gourhari; KURHADE, Sanjay, Pralhad; JAGDALE, Arun, Rangnath; KUKREJA, Gagan; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar
Patent: WO2014/9872 A1, 2014 ;
Location in patent: Page/Page column 70 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20 - 60°C;
参考文献
US2005/9841 A1, ;
Page/Page column 14 ;
反应条件
ammonium hydroxide in methanol T=20°C;
参考文献
US2005/80095 A1, ;
Page/Page column 19 ;
反应条件
sodium hydroxide; tris-(dibenzylideneacetone)dipalladium(0) in dichloromethane
参考文献
Bjorsne, Magnus; Hoffmann, Kurt-Jurgen; Ponten, Fritiof; Strandlund, Gert; Svensson, Peder; Wilstermann, Michael
Patent: US2004/23971 A1, 2004 ;
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Barlocco, Daniela; Cignarella, Giorgio; Tondi, Donatella; Vianello, Paola; Villa, Stefania; Bartolini, Alessandro; Ghelardini, Carla; Galeotti, Nicoletta; Anderson, David J.; Kuntzweiler, Theresa A.; Colombo, Diego; Toma, Lucio
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 674 - 681
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 5 h; Heating;
参考文献
Liu, Hong; Cheng, Tie-Ming; Zhang, Hong-Mei; Li, Run-Tao
Archiv der Pharmazie, 2003 , vol. 336, # 11 p. 510 - 513
反应条件
1: 90 percent / K2CO3 / acetone / Heating 2: 95 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 5 p. 674 - 681
反应条件
1: 90 percent / K2CO3 / acetone / Heating 2: 95 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 5 p. 674 - 681
反应条件
1: 97 percent / CH2Cl2 / Ambient temperature 2: 100 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature View Scheme
参考文献
Barlocco, Daniela; Cignarella, Giorgio; Tondi, Donatella; Vianello, Paola; Villa, Stefania; Bartolini, Alessandro; Ghelardini, Carla; Galeotti, Nicoletta; Anderson, David J.; Kuntzweiler, Theresa A.; Colombo, Diego; Toma, Lucio
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 674 - 681
