(2S,4s)-4-烯丙基-1-(叔丁氧基羰基)吡咯烷-2-羧酸合成路线 （共 7 条）
参考文献
Borzilleri, Robert M.; Zhang, Yong; Miller, Michael M.; Seigal, Benjamin A.
Patent: US2014/135270 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C
1.2: H2O2 / tetrahydrofuran / 0.33 h / 0 °C
1.3: 89 percent / triethylsilane; BF3*OEt2 / CH2Cl2 / 3 h / -78 °C
2.1: 86 percent / NaOH / methanol; H2O / 6 h / 20 °C
View Scheme
参考文献
Kondo, Takashi; Sugimoto, Isamu; Nekado, Takahiro; Ochi, Kenya; Ohtani, Tazumi; Tajima, Yohei; Yamamoto, Susumu; Kawabata, Kazuhito; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2715 - 2735
反应条件
1.1: 4-(dimethylamino)pyridine / acetonitrile
2.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C
2.2: H2O2 / tetrahydrofuran / 0.33 h / 0 °C
2.3: 89 percent / triethylsilane; BF3*OEt2 / CH2Cl2 / 3 h / -78 °C
3.1: 86 percent / NaOH / methanol; H2O / 6 h / 20 °C
View Scheme
参考文献
Kondo, Takashi; Sugimoto, Isamu; Nekado, Takahiro; Ochi, Kenya; Ohtani, Tazumi; Tajima, Yohei; Yamamoto, Susumu; Kawabata, Kazuhito; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2715 - 2735
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran
1.2: tetrahydrofuran
2.1: trifluoroacetic acid / CH2Cl2
2.2: toluene / Heating
3.1: 4-(dimethylamino)pyridine / acetonitrile
4.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C
4.2: H2O2 / tetrahydrofuran / 0.33 h / 0 °C
4.3: 89 percent / triethylsilane; BF3*OEt2 / CH2Cl2 / 3 h / -78 °C
5.1: 86 percent / NaOH / methanol; H2O / 6 h / 20 °C
View Scheme
参考文献
Kondo, Takashi; Sugimoto, Isamu; Nekado, Takahiro; Ochi, Kenya; Ohtani, Tazumi; Tajima, Yohei; Yamamoto, Susumu; Kawabata, Kazuhito; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2715 - 2735
反应条件
1.1: 4-(dimethylamino)pyridine / acetonitrile
2.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C
2.2: H2O2 / tetrahydrofuran / 0.33 h / 0 °C
2.3: 89 percent / triethylsilane; BF3*OEt2 / CH2Cl2 / 3 h / -78 °C
3.1: 86 percent / NaOH / methanol; H2O / 6 h / 20 °C
View Scheme
参考文献
Kondo, Takashi; Sugimoto, Isamu; Nekado, Takahiro; Ochi, Kenya; Ohtani, Tazumi; Tajima, Yohei; Yamamoto, Susumu; Kawabata, Kazuhito; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2715 - 2735
反应条件
1.1: trifluoroacetic acid / CH2Cl2
1.2: toluene / Heating
2.1: 4-(dimethylamino)pyridine / acetonitrile
3.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C
3.2: H2O2 / tetrahydrofuran / 0.33 h / 0 °C
3.3: 89 percent / triethylsilane; BF3*OEt2 / CH2Cl2 / 3 h / -78 °C
4.1: 86 percent / NaOH / methanol; H2O / 6 h / 20 °C
View Scheme
参考文献
Kondo, Takashi; Sugimoto, Isamu; Nekado, Takahiro; Ochi, Kenya; Ohtani, Tazumi; Tajima, Yohei; Yamamoto, Susumu; Kawabata, Kazuhito; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2715 - 2735
反应条件
1: lithium hexamethyldisilazane; acetic acid / tetrahydrofuran; toluene; ethyl acetate; hexane
2: dihydrogen peroxide; triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran; ethyl acetate; hexane; water
3: tetrahydrofuran
View Scheme
参考文献
Borzilleri, Robert M.; Zhang, Yong; Miller, Michael M.; Seigal, Benjamin A.
Patent: US2014/135270 A1, 2014 ;
