2-氨基-N-[3-[N-[3-[(2-氯-5-甲氧基苯基)氨基]喹喔啉-2-基]氨基磺酰基]苯基]-2-甲基丙酰胺合成路线 （共 5 条）
反应条件
1: in N,N-dimethyl-formamide
T=5°C; Large scale;
2: With dipotassium hydrogenphosphate in ethanol; water; N,N-dimethyl-formamide
T=10°C; 2 h; Large scale;
参考文献
SANOFI; PARIKH, Darshan; RAJU, Praveen
Patent: WO2014/41142 A1, 2014 ;
Location in patent: Page/Page column 25 ;
反应条件
in N,N-dimethyl-formamide
T=5°C; Large scale;
参考文献
SANOFI; BAILLON, Bruno; BAULIER, Virginie; COMTE, Myriam; FUGIER, Matthieu; KOZLOVIC, Stéphane; PERRIN, Marc-Antoine
Patent: WO2014/41144 A1, 2014 ;
Location in patent: Paragraph 00172; 00173; 00174 ;
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / |Reflux; |Large scale
2.1: platinum sulfide on carbon / tetrahydrofuran; water; ethanol / |Reflux; |Large scale
2.2: |Reflux; |Large scale
2.3: 20 °C / |Large scale
3.1: N,N-dimethyl-formamide / 5 °C / |Large scale
View Scheme
参考文献
SANOFI; BAILLON, Bruno; BAULIER, Virginie; COMTE, Myriam; FUGIER, Matthieu; KOZLOVIC, Stéphane; PERRIN, Marc-Antoine
Patent: WO2014/41144 A1, 2014 ;
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / |Reflux; |Large scale
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / |Reflux; |Large scale
3.1: platinum sulfide on carbon / tetrahydrofuran; water; ethanol / |Reflux; |Large scale
3.2: |Reflux; |Large scale
3.3: 20 °C / |Large scale
4.1: N,N-dimethyl-formamide / 5 °C / |Large scale
View Scheme
参考文献
SANOFI; BAILLON, Bruno; BAULIER, Virginie; COMTE, Myriam; FUGIER, Matthieu; KOZLOVIC, Stéphane; PERRIN, Marc-Antoine
Patent: WO2014/41144 A1, 2014 ;
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / |Reflux; |Large scale
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / |Reflux; |Large scale
3.1: platinum sulfide on carbon / tetrahydrofuran; water; ethanol / |Reflux; |Large scale
3.2: |Reflux; |Large scale
3.3: 20 °C / |Large scale
4.1: N,N-dimethyl-formamide / 5 °C / |Large scale
View Scheme
参考文献
SANOFI; BAILLON, Bruno; BAULIER, Virginie; COMTE, Myriam; FUGIER, Matthieu; KOZLOVIC, Stéphane; PERRIN, Marc-Antoine
Patent: WO2014/41144 A1, 2014 ;
