4-氨基-3-氟-哌啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
hydrogen; palladium(II) oxide hydrate in methanol
4 h;
参考文献
Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
Patent: US2010/324030 A1, 2010 ;
Location in patent: Page/Page column 22 ;
反应条件
1: With 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=20°C; 2 h;
2: With ammonium acetate in methanol
T=20°C; 2 h;
3: With sodium cyanoborohydride in methanol
T=20°C; 4 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/90330 A1, 2005 ;
Location in patent: Page/Page column 78-79 ;
WO 2005/090330 A1
反应条件
sodium hydrogencarbonate in water; ethyl acetate
T=20°C; 1 h;
参考文献
Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
Patent: US2010/324030 A1, 2010 ;
Location in patent: Page/Page column 22 ;
