2-[3-羟基-1-[(苯基甲氧基)羰基]-3-氮杂啶]-1-哌啶羧酸 1,1-二甲基乙酯合成路线 （共 2 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; iso-butyllithium in diethyl ether; cyclohexane
T=-78 - 20°C;
参考文献
EXELIXIS, INC.
Patent: WO2008/124085 A2, 2008 ;
Location in patent: Page/Page column 182 ;
WO 2008/124085 A2
反应条件
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; iso-butyllithium in diethyl ether; cyclohexane
T=-78°C;
2: N-(Benzyloxycarbonyl)azetidin-3-one in diethyl ether; cyclohexane
T=-60 - 20°C;
参考文献
EXELIXIS, INC.
Patent: WO2007/44515 A1, 2007 ;
Location in patent: Page/Page column 168 ;
WO 2007/044515 A1
