6-氟-7-硝基-2(1H)-喹喔啉酮合成路线 （共 3 条）
反应条件
nitric acid; acetic acid
T=20°C; 18 h;
参考文献
Aoki, Katsuyuki; Obata, Tatsuhiro; Yamazaki, Yosuke; Mori, Yoshikazu; Hirokawa, Hiroko; Koseki, Jun-Ichi; Hattori, Tomohisa; Niitsu, Kazuaki; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-Ichi
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 2 p. 255 - 267
反应条件
1: 44 percent / K2CO3 / dimethylformamide; H2O / 1 h / 80 °C
2: H2 / Pd/C / ethanol / 20 °C
3: aq. H2O2; NaOH / methanol / 1.5 h / 100 °C
4: 65 percent / HNO3; AcOH / 18 h / 20 °C
View Scheme
参考文献
Aoki, Katsuyuki; Obata, Tatsuhiro; Yamazaki, Yosuke; Mori, Yoshikazu; Hirokawa, Hiroko; Koseki, Jun-Ichi; Hattori, Tomohisa; Niitsu, Kazuaki; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-Ichi
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 2 p. 255 - 267
反应条件
1: H2 / Pd/C / ethanol / 20 °C
2: aq. H2O2; NaOH / methanol / 1.5 h / 100 °C
3: 65 percent / HNO3; AcOH / 18 h / 20 °C
View Scheme
参考文献
Aoki, Katsuyuki; Obata, Tatsuhiro; Yamazaki, Yosuke; Mori, Yoshikazu; Hirokawa, Hiroko; Koseki, Jun-Ichi; Hattori, Tomohisa; Niitsu, Kazuaki; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-Ichi
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 2 p. 255 - 267
