N-[(1S,3S)-3-[4-甲氧基-3-(3-甲氧基丙氧基)苯甲酰基]-4-甲基-1-[(2S,4S)-四氢-4-异丙基-5-氧代-2-呋喃基]戊基]-氨基甲酸叔丁酯合成路线 （共 7 条）
反应条件
citric acid in water
T=65°C; 2 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 67-68 ;
反应条件
1: 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene With n-butyllithium in tetrahydrofuran; hexane
T=-70°C; 2 h;
2: (3S,5S)-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxotetrahydro-furan-2-yl)-2-oxopyrrolidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran; hexane
T=-70 - -50°C;
3: With water; citric acid in tetrahydrofuran; hexane
T=0 - 5°C; 0.333333 h;
参考文献
NOVARTIS AG
Patent: WO2008/119804 A1, 2008 ;
Location in patent: Page/Page column 65-66 ;
WO 2008/119804 A1
反应条件
in tetrahydrofuran
T=-70°C; 0.583333 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 68-69 ;
反应条件
in tetrahydrofuran
T=-10°C; 16 - 17 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 67-68 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; water
T=20°C; 68 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 72-73 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; acetic acid
T=50°C; P=3750.38 Torr; 46 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 69-72 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; water
T=20°C; 68 h;
参考文献
NOVARTIS AG
Patent: WO2008/119804 A1, 2008 ;
Location in patent: Page/Page column 67-68 ;
WO 2008/119804 A1
