hydrogenchloride in 1,4-dioxane; water 4 h; Heating;

<b>Multi-step reaction with 3 steps<br /> </b>1: 79 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature<br />2: 1) tert-butyllithium / 1) THF, -78 deg C, 1.5 h; 2) THF, -78 deg C, 30 min<br />3: 65 percent / tetrahydrofuran / 0.5 h / -78 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 79 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature<br />2: 1) tert-butyllithium / 1) THF, -78 deg C, 1.5 h; 2) THF, -78 deg C, 30 min<br />3: 65 percent / tetrahydrofuran / 0.5 h / -78 &deg;C<br /> <br /> &nbsp;