2,3-二氢-1-氧代阿塞那平; 5-氯-2-甲基-2,3-二氢二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯-(2H)-酮合成路线 （共 9 条）
反应条件
1.1: potassium carbonate; copper / o-xylene / 25 - 30 °C / Reflux 2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C 2.2: 0 - 30 °C 3.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere 3.2: 0 - 5 °C / pH 2 - 2.5 4.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C View Scheme
反应条件
1.1: caesium carbonate / copper(l) chloride; N,N-dimethylaminoacetic acid / 1,4-dioxane / 110 - 115 °C 1.2: 5 h / 25 - 65 °C 2.1: hydrogenchloride / dichloromethane; water / pH 1.5 2.2: 0.75 h / 0 - 15 °C 3.1: potassium tert-butylate / toluene / 3 h / 20 °C 3.2: 3 h / 20 °C 4.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C View Scheme
反应条件
1.1: potassium carbonate; copper / o-xylene / 25 - 30 °C / Reflux 2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C 2.2: 0 - 30 °C 3.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere 3.2: 0 - 5 °C / pH 2 - 2.5 4.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C View Scheme
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C 1.2: 0 - 30 °C 2.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere 2.2: 0 - 5 °C / pH 2 - 2.5 3.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C View Scheme
反应条件
1.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere 1.2: 0 - 5 °C / pH 2 - 2.5 2.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C View Scheme
反应条件
1.1: potassium tert-butylate / toluene / 3 h / 20 °C 1.2: 3 h / 20 °C 2.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C View Scheme
反应条件
1.1: hydrogenchloride / dichloromethane; water / pH 1.5 1.2: 0.75 h / 0 - 15 °C 2.1: potassium tert-butylate / toluene / 3 h / 20 °C 2.2: 3 h / 20 °C 3.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C View Scheme
反应条件
1.1: magnesium / methanol / 25 - 65 °C / Reflux 2.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / -5 - 5 °C 2.2: -5 - 5 °C 3.1: isopropyl alcohol / 60 °C View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; POLAVARAPU, Srinivas; YADDANAPUDI, Venkata Madhavi; VINIGARI, Krishna; PAGADALA, Narasimha Rao; SAGYAM, Rajeshwar Reddy
Patent: WO2011/159903 A2, 2011 ;
反应条件
1.1: magnesium / methanol / 25 - 65 °C / Reflux 2.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / -5 - 5 °C 2.2: -5 - 5 °C View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; POLAVARAPU, Srinivas; YADDANAPUDI, Venkata Madhavi; VINIGARI, Krishna; PAGADALA, Narasimha Rao; SAGYAM, Rajeshwar Reddy
Patent: WO2011/159903 A2, 2011 ;
