(S)-(-)-7-甲氧基-n-丙基-2-氨基四氢化萘盐酸盐合成路线 （共 2 条）
反应条件
1: With (+)-4-(2-chlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide in ethanol
HeatingResolution of racemate;
2: With water; sodium hydroxide
T=20°C; 2 h;
3: With hydrogenchloride
参考文献
Ghosh, Balaram; Antonio, Tamara; Gopishetty, Bhaskar; Reith, Maarten; Dutta, Aloke
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5661 - 5674
反应条件
1: 100 percent / 5percent aq. NaOH / CH2Cl2 / 0.5 h
2: 90 percent / LiAlH4 / diethyl ether
3: BBr3 / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Wikstroem, Hakan; Andersson, Bengt; Sanchez, Domingo; Lindberg, Per; Arvidsson, Lars-Erik; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 215 - 225
