4-(4-甲基-5-(2-(三氟甲基)苯基)-4H-1,2,4-噻唑-3-基)双环[2.2.2]辛烷-1-羧酸合成路线 (共 1 条)
反应条件
1: With 1,1'-carbonyldiimidazole in dichloromethane
T=20°C; 2 h;
2: With ammonia in dichloromethane; water
18 h;
参考文献
Balkovec, James M.; Thieringer, Rolf; Waddell, Sherman T.
Patent: US2008/262051 A1, 2008 ;
Location in patent: Page/Page column 11 ;