3,3-二氟环丁烷羧酸苄酯合成路线 （共 5 条）
反应条件
diethylamino-sulfur trifluoride in dichloromethane T=20°C; 16 h; Inert atmosphere;
参考文献
AGIOS PHARMACEUTICALS, INC.; Popovici-Muller, Janeta; SAUNDERS, Jeffrey, O.; SALITURO, Francesco, G.; CAI, Zhenwei; YAN, Shunqi; ZHOU, Ding
Patent: WO2013/107405 A1, 2013 ;
Location in patent: Page/Page column 42 ;
反应条件
1: potassium carbonate / hexadeuterioacetone; hexane 2: diethylamino-sulfur trifluoride View Scheme
反应条件
1: potassium carbonate / acetone / 16 h / |Reflux 2: diethylamino-sulfur trifluoride / dichloromethane / 16 h / 20 °C / |Inert atmosphere View Scheme
反应条件
1: potassium carbonate / acetone / 16 h / |Reflux 2: diethylamino-sulfur trifluoride / dichloromethane / 16 h / 20 °C / |Inert atmosphere View Scheme
反应条件
palladium on activated charcoal; hydrogen in ethanol T=20°C; 12 h;
参考文献
WO2013/107405 A1, ;
Page/Page column 42 ;
