1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: NaBH4 / ethanol / 1 h / Ambient temperature 5: 16 percent / SOCl2, Et3N / CHCl3 / 0.5 h / Ambient temperature View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: 44 percent / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: NaBH4 / ethanol / 1 h / Ambient temperature 5: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 1 h View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: NaBH4 / ethanol / 1 h / Ambient temperature 5: 82 percent / CH2Cl2 / 1 h / Heating View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: m-CPB 5: 11 percent / t-BuOK / tetrahydrofuran / 2 h / -15 °C View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: 31 percent / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: 12 percent / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature View Scheme