反应条件
1: 1.) n-BuLi / 1.) THFm HMPA, hexane, -80 deg C -> -30 deg C, 30 min; -30 deg C, 45 min, 2.) room temperature, 30 h
2: 87 percent / CBr4, Ph3P / CH2Cl2 / 0.75 h
3: 2.) CuCl / 1.) THF, room temperature, 2.5 h, 2.) 40 deg C, 3 h
4: 96 percent / Ni(OAc)4*4H2O, NaBH4, H2, ethylenediamine / aq. ethanol / 4 h
5: 69 percent / CBr4, Ph3P / CH2Cl2 / 0 °C
6: 142 mg / 12M HCl / methanol; tetrahydrofuran / 24 h / 0 °C
View Scheme
参考文献
Mosset, Paul; Gree, Rene; Falck, J. R.
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 645 - 658
