triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane; acetonitrile T=20°C; 10 h;

1: 1-bromo-4-fluorobenzene With magnesium; ethylene dibromide in tetrahydrofuran T=20°C; 0.666667 h; Inert atmosphere; 2: N-methoxy-N-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)acetamide in tetrahydrofuran T=0°C; 3 h; Inert atmosphere;

1: N,N-dimethyl-formamide / 10 h / 90 °C 2: potassium carbonate; methanol / 2 h / 20 °C 3: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane; acetonitrile / 10 h / 20 °C View Scheme

1: potassium carbonate; methanol / 2 h / 20 °C 2: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane; acetonitrile / 10 h / 20 °C View Scheme