6-溴-2-氟-3-羟基苯甲醛合成路线 （共 2 条）
反应条件
1: With boron tribromide in dichloromethane
T=-78 - 20°C; Inert atmosphere;
2: With water in dichloromethane
参考文献
ANACOR PHARMACEUTICALS, INC; JARNAGIN, Kurt; AKAMA, Tsutomu
Patent: WO2011/94450 A1, 2011 ;
Location in patent: Page/Page column 149-150 ;
反应条件
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 0 °C / Inert atmosphere
1.2: 1 h / -78 - 20 °C
2.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
ANACOR PHARMACEUTICALS, INC; JARNAGIN, Kurt; AKAMA, Tsutomu
Patent: WO2011/94450 A1, 2011 ;
