2-氨基-5-溴-4-三氟甲基嘧啶合成路线

参考文献

US2013/225574 A1, ;

Paragraph 0506; 0507 ;

参考文献

Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779

935534-47-72-氨基-5-溴-4-三氟甲基嘧啶+

73183-34-3联硼酸频那醇酯

944401-58-52-氨基-4-三氟嘧啶-5-硼酸频哪醇酯+

16075-42-64-三氟甲基-2-氨基嘧啶

参考文献

Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779

935534-47-72-氨基-5-溴-4-三氟甲基嘧啶+

73183-34-3联硼酸频那醇酯

944401-58-52-氨基-4-三氟嘧啶-5-硼酸频哪醇酯

参考文献

NOVARTIS AG; Fairhurst, Robin Alec; Furet, Pascal; Kalthoff, Frank Stephan; Lerchner, Andreas; Rueeger, Heinrich
Patent: US2014/135330 A1, 2014 ;
Location in patent: Paragraph 0218 ;

935534-47-72-氨基-5-溴-4-三氟甲基嘧啶+

73183-34-3联硼酸频那醇酯

944401-58-52-氨基-4-三氟嘧啶-5-硼酸频哪醇酯+

16075-42-64-三氟甲基-2-氨基嘧啶

参考文献

Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779