1-氰基-2-苯基乙铵氯化物合成路线 （共 16 条）
反应条件
triethylamine in dichloromethane
5 h; Ambient temperature;
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
反应条件
1: 94 percent / Et3N / CH2Cl2 / 5 h / Ambient temperature
2: 73 percent / BF3*Et2O / CH2Cl2 / 4.5 h / 0 °C
View Scheme
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
反应条件
1: 91 percent / Et3N / CH2Cl2 / 5 h / Ambient temperature
2: 100 percent / BF3*Et2O / CHCl3 / 0 deg C, 1 h, -> RT, 5 h
View Scheme
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
反应条件
1: 85 percent / Et3N / CH2Cl2 / 5 h / Ambient temperature
2: 63 percent / BF3*Et2O / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
反应条件
in water
Alkaline aqueous solution;
参考文献
DSM IP Assets B.V.
Patent: EP1352894 A1, 2003 ;
Location in patent: Page/Page column 5 ;
反应条件
1: 69 percent / hydroxybenzotriazole; EDC; pyridine / CH2Cl2 / 15 h / 20 °C
2: CH2Cl2 / 1.5 h / 0 °C
3: NH2OH*HCl; Na2CO3 / ethanol; H2O / 19 h / 20 - 70 °C
4: H2 / Raney-Ni W2 / methanol / 3 h / 20 °C / atmospheric pressure
5: pyridine / 1 h / 20 °C
6: 91 percent / NaH / tetrahydrofuran / 2 h / 20 °C
7: 85 percent / i-Pr2NEt / CH2Cl2 / 2 h / 0 °C
8: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
9: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Usami, Ken; Isobe, Minoru
Tetrahedron, 1996 , vol. 52, # 37 p. 12061 - 12090
