3-甲氧基-alpha-[(三甲基硅烷基)氧基]-苯乙腈合成路线 （共 3 条）
反应条件
hydrogenchloride; water T=70°C;
参考文献
Weist, Stefan; Kittel, Claudia; Bischoff, Daniel; Bister, Bojan; Pfeifer, Volker; Nicholson, Graeme J.; Wohlleben, Wolfgang; Suessmuth, Roderich D.
Journal of the American Chemical Society, 2004 , vol. 126, # 19 p. 5942 - 5943
反应条件
1: n-butyllithium; 3-methoxy-α-[(trimethylsilyl)oxy]benzeneacetonitrile With diisopropylamine in tetrahydrofuran; hexane T=-70°C; Metallation; 0.5 h; 2: 1-bromo-3-chloro-propane in tetrahydrofuran; hexane T=20°C; Alkylation; 2 h; Further stages.;
参考文献
Perrone, Roberto; Berardi, Francesco; Colabufo, Nicola A.; Leopoldo, Marcello; Tortorella, Vincenzo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 270 - 277
反应条件
Yield given. Multistep reaction;
参考文献
Perrone, Roberto; Berardi, Francesco; Colabufo, Nicola A.; Leopoldo, Marcello; Tortorella, Vincenzo
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 10 p. 1327 - 1330
